# Director, Portfolio Management at AstraZeneca

AstraZeneca is hiring a Director, Portfolio Management. It pays $159k-$209k a year and Level rates it Little AI ●○○○; you can [apply on AstraZeneca](https://jobsbylevel.com/go/ed50fbe8-e7e1-4152-8e69-a1f6af806852?utm_medium=ai-agent).

AI Level 1, AI centrality 36 out of 100. US - Gaithersburg - MD.

## Details

- Company: [AstraZeneca](https://jobsbylevel.com/companies/astrazeneca)
- AI level: AI Level 1 (score 36 out of 100)
- Location: US - Gaithersburg - MD
- Salary: $159k-$209k
- Posted: November 13, 2026
- Apply: https://jobsbylevel.com/go/ed50fbe8-e7e1-4152-8e69-a1f6af806852?utm_medium=ai-agent
- Free CV review for this job: https://jobsbylevel.com/cv-review?job=director-portfolio-management-at-astrazeneca-c43381

## Description

WHY JOIN US? At AstraZeneca, we are dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. With an ambitious goal of delivering 20 new medicines by 2030, there is no better place to make a difference in medicine, for patients, and in society. Join us on this exciting journey to pioneer the future of healthcare. Our inclusive culture champions diversity and collaboration, and we are always committed to lifelong learning, growth, and development. As part of our team, you'll contribute to groundbreaking advancements that will shape a healthier future for people everywhere. Be a catalyst for change at AstraZeneca, where your work will have a real impact on improving people's lives. Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week . Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects. About AISI AstraZeneca AI for Science Innovation (AISI) is driving the convergence of artificial intelligence and life sciences at enterprise scale. AISI brings together data foundations, AI and machine-learning technology, strategic partnerships, process reinvention, and business-facing AI to accelerate drug discovery, development, and delivery. Success depends on connecting and scaling existing capabilities, promoting reuse, and translating innovation into measurable scientific, patient, and enterprise value. The Opportunity The Director, Portfolio Management will lead the design, governance, and continuous improvement of AISI's portfolio management capability across strategic initiatives, AI and data platforms, external partnerships, projects, suppliers, managed services, and operational investments. The role ensures that strategy is translated into an executable portfolio, investments and resources are directed to the highest-value opportunities, delivery performance is transparent, and financial and operational risk, and compliance governance are embedded throughout the portfolio lifecycle. Operating at the intersection of AISI leadership, scientific and therapeutic-area stakeholders, Data Science, Engineering, Finance, Procurement, HR, and external partners, the Director will establish scalable ways of working, strengthen evidence-based decision-making, and deliver outcomes through cross-functional teams and managed-service providers. The role sits within AISI Operations and reports to the Head of AISI Operations. Scope and Core Accountabilities Portfolio Strategy, Planning, and Governance Translate AISI strategy and scientific priorities into an integrated portfolio of investments, initiatives, platforms, products, partnerships, and operational services. Establish and continuously improve demand intake, assessment, value-based prioritization, funding, resource allocation, stage-gate review, delivery assurance, and benefits-realization processes. Maintain an integrated portfolio view, identifying opportunities to stop, sequence, accelerate, consolidate, reuse, or scale initiatives as priorities and evidence evolve. Lead portfolio governance forums and provide clear executive reporting on investment, demand, delivery health, dependencies, risks, issues, decisions, capacity, financial performance, and expected value. Develop standardized dashboards and management information that enable timely, transparent, evidence-based decisions without creating unnecessary bureaucracy. Financial and Investment Management Partner with Finance and senior leaders to manage long-term investment planning, business cases, budgets, forecasts, and Run and Change expenditure. Oversee forecast-versus-budget analysis, variance management, accruals,

The description is cut here. Read the full offer: https://jobsbylevel.com/jobs/director-portfolio-management-at-astrazeneca-c43381

Source: https://jobsbylevel.com/jobs/director-portfolio-management-at-astrazeneca-c43381

## Cite this page

Level. https://jobsbylevel.com/jobs/director-portfolio-management-at-astrazeneca-c43381.

Get job alerts: https://jobsbylevel.com/newsletter