# Head of Medical Affairs at Calico Labs

Calico Labs is hiring a Head of Medical Affairs in South San Francisco, United States. It pays $310k-$420k a year and Level rates it Little AI ●○○○; you can [apply on Level](https://jobsbylevel.com/go/5c2d4024-937c-4bda-8fc6-86e85aa0a651).

AI Level 1, AI centrality 36 out of 100. South San Francisco, CA.

## Details

- Company: [Calico Labs](https://jobsbylevel.com/companies/calico-labs)
- AI level: AI Level 1 (score 36 out of 100)
- Location: South San Francisco, CA
- Salary: $310k-$420k
- Posted: October 9, 2026
- Apply: https://jobsbylevel.com/go/5c2d4024-937c-4bda-8fc6-86e85aa0a651

## Description

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. The Opportunity: Calico’s commitment to discovery science led us to Vanishing White Matter (VWM), a rare disease leukodystrophy where chronic dysregulation of the Integrated Stress Response drives disease pathology. Driven by rigorous research, we are dedicated to advancing potential therapies and preparing for the anticipated global launch of Calico's first commercial therapy. To achieve this, we are looking for passionate, driven individuals to build a dedicated team focused on delivering meaningful treatment options to VWM patients and families facing severe unmet medical needs. Position Description: Calico is seeking a highly strategic Head of Medical Affairs to establish and lead our medical affairs function, translating clinical science into a differentiated, evidence-based narrative for global markets, with an initial emphasis on VWM therapy in US markets. This role reports to the Head of Clinical Development and will be responsible for shaping medical affairs strategy, building infrastructure, hiring and leading our field medical and medical information teams, and accelerating disease-state awareness. Closely collaborating with molecule teams in R&D, they will be serving as a key leader on launch teams as molecules approach approval and a key voice of medicine across the organization. Key Responsibilities: Strategy & Leadership Lead, develop and execute the global medical affairs strategy in alignment with Clinical, Regulatory, and Commercial priorities Serve as the Medical Affairs lead on the cross-functional launch team Build out core Medical Affairs capabilities to support the launch, including medical communications, field medical team, and post-marketing support functions as needed Establish and oversee the external Medical Communications and Medical Information functions, including leading publication planning and execution, developing standard response letters, building global FAQs, and building the infrastructure to efficiently handle unsolicited medical inquiries post-launch Scientific Engagement Cultivate and maintain trusted relationships with global leading Key Opinion Leaders (KOLs), clinical investigators, and expert centers in the rare disease space Understand areas of scientific interests and gaps - Design and execute medical education initiatives, advisory boards, and scientific exchange programs Lead the development of scientific messaging platform, publication strategy and scientific communication plans Develop and implement, in partnership with Commercial colleagues, initiatives aimed at reducing the diagnostic journey, including physician education, screening initiatives, genetic testing efforts, and partnerships with diagnostic specialists and labs Partner closely with rare disease patient advocacy organizations to ensure the patient voice is deeply embedded in our medical strategy Evidence Generation and Compliance Oversee early access programs, investigator-sponsored research, and real-world evidence initiatives to support the full product lifecycle Design and execute post-marketing requirements and commitments while establishing medical information capabilities and standard response documents Collaborate cross-functionally on data interpretation and label optimization Ensure all Medical Affairs activities comply with applicable regulations, industry codes, and internal policies

The description is cut here. Read the full offer: https://jobsbylevel.com/jobs/head-of-medical-affairs-at-calico-labs-fb9090

Source: https://jobsbylevel.com/jobs/head-of-medical-affairs-at-calico-labs-fb9090

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