# Principal /Senior Principal Scientist - Toxicology at Roche

Roche is hiring a Principal /Senior Principal Scientist - Toxicology in Shanghai, China. Level rates it Little AI ●○○○; you can [apply on Roche](https://jobsbylevel.com/go/5de0fe2d-c4f4-4b4c-bdb0-480e63e1fae5?utm_medium=ai-agent).

AI Level 1, AI centrality 0 out of 100. Shanghai.

## Details

- Company: [Roche](https://jobsbylevel.com/companies/roche)
- AI level: AI Level 1 (score 0 out of 100)
- Location: Shanghai
- Posted: August 4, 2026
- Apply: https://jobsbylevel.com/go/5de0fe2d-c4f4-4b4c-bdb0-480e63e1fae5?utm_medium=ai-agent
- Free CV review for this job: https://jobsbylevel.com/cv-review?job=principal-senior-principal-scientist-toxicology-at-roche-cdc5ba

## Prepare for this job

The job page lists 4 likely interview questions for this offer, with a CV checklist: https://jobsbylevel.com/jobs/principal-senior-principal-scientist-toxicology-at-roche-cdc5ba

## Description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position Position: We are seeking a highly motivated and experienced Principal/Senior Principal Toxicologist to provide translational safety leadership for Genentech's growing China development portfolio. The successful candidate will serve as the China Translational Safety scientific and regulatory lead, partnering closely with gRED Translational Safety colleagues and cross-functional teams to support drug discovery and development efforts and due diligence activities across all therapeutic areas. This individual will provide strategic guidance for China-specific development, regulatory interactions, and safety assessment while ensuring alignment with global development strategies. The role requires deep expertise in toxicology, nonclinical safety and PK study design and execution, compliance with international guidelines, CRO study oversight and China's evolving regulatory landscape, combined with the ability to influence across functions, organizations, and geographic regions. Scope of the position: The Principal/Senior Principal Toxicologist will: Serve as the China subject matter expert (SME) for translational safety and China regulatory requirements supporting China development programs in collaboration with gRED Translational Safety colleagues. Partner closely with gRED project toxicologists to optimize safety strategies for China development, registration and lifecycle management. Build productive scientific relationships with China regulatory authorities (e.g., NMPA/CDE) and CRO partners. Provide onsite technical oversight of the toxicology studies conducted at Contract Research Organizations (CROs) in China and other countries in Asia. Will serve as the Translational Safety lead for Asia Partnering and participate in due diligence activities with potential China partners. Represent Translational Safety on China governance committees and cross-functional development teams as needed. Drive scientific excellence by incorporating innovative approaches, including Weight of Evidence (WoE) and New Approach Methodologies (NAMs), into nonclincial safety assessment. Responsibilities: Leads the nonclinical safety assessment of Genentech Research and Early Development (gRED) therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement. Scientific leadership in the design and implementation of translational safety strategies to support program advancement and decision-making. Investigate mechanisms of toxicity. Proactive management of potential safety liabilities and communication of impact to teams and governance committees. Closely collaborate with pathologists, study operations professionals, pharmacokineticists, and pharmaceutics to create streamlined, innovative translation safety programs for Genentech drug candidates; and to author regulatory documents. Closely collaborate with predictive toxicologists to incorporate NAM approaches (e.g. in silico, in vitro models) into safety strategies. Work independently to leverage literature to develop and optimize best-evidence arguments in support of data interpretation or experimental approaches. Partner with the colleagues in China Innovation center of Roche (CiCOR) on nonclinical safety strategies, regulatory interactions, and CRO oversight Provide onsite technical oversight of the toxicology studies conducted at CROs. Conduct due diligence

The description is cut here. Read the full offer: https://jobsbylevel.com/jobs/principal-senior-principal-scientist-toxicology-at-roche-cdc5ba

Source: https://jobsbylevel.com/jobs/principal-senior-principal-scientist-toxicology-at-roche-cdc5ba

## Cite this page

Level. https://jobsbylevel.com/jobs/principal-senior-principal-scientist-toxicology-at-roche-cdc5ba.

Get job alerts: https://jobsbylevel.com/newsletter