# Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences (Cambridge, MA or Gaithersburg, MD) at AstraZeneca

AstraZeneca is hiring a Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences (Cambridge, MA or Gaithersburg, MD). It pays $185k-$277k a year and Level rates it Little AI ●○○○; you can [apply on AstraZeneca](https://jobsbylevel.com/go/714b90c1-543b-4d1f-88b1-a41fc2c03454?utm_medium=ai-agent).

AI Level 1, AI centrality 35 out of 100. US - Gaithersburg - MD.

## Details

- Company: [AstraZeneca](https://jobsbylevel.com/companies/astrazeneca)
- AI level: AI Level 1 (score 35 out of 100)
- Location: US - Gaithersburg - MD
- Salary: $185k-$277k
- Posted: August 21, 2026
- Apply: https://jobsbylevel.com/go/714b90c1-543b-4d1f-88b1-a41fc2c03454?utm_medium=ai-agent
- Free CV review for this job: https://jobsbylevel.com/cv-review?job=project-toxicologist-director-oncology-targeted-delivery-otd-safety-science-clinical-pharmacology-and-safety-sciences-cambridge-ma-or-gaithersburg-md-at-astrazeneca-147e5f

## Description

At AstraZeneca , our ambition is to eliminate cancer as a cause of death. Our pioneering oncology pipeline reflects this mission, and our Oncology Targeted Delivery (OTD) Safety team plays a critical role in advancing transformative therapies to patients. We are seeking a passionate and highly motivated Director, Project Toxicologist to join our OTD Safety group. This role will focus on novel targeted oncology therapies, including radioconjugates, antibody–drug conjugates (ADCs), and small molecules . Experience with radioconjugates is particularly valued; however, candidates with expertise in other relevant modalities are encouraged to apply. As a Project Toxicologist, you will partner with cross-functional teams across Oncology R&D, bridging discovery and regulatory toxicology. You will develop innovative safety strategies, guide candidate selection, inform regulatory approaches, and help shape the future of oncology safety science. LOCATIONS: Cambridge, MA (Kendall Square) or Gaithersburg, MD What you’ll do Lead toxicology strategies : Design and oversee regulatory and investigative toxicology programs to predict, assess, and mitigate target- and modality-related safety risks. Support development decisions : Apply your toxicology expertise to anticipate clinical safety risks and provide data-driven recommendations across discovery and development programs. Advance safety science : Integrate in vitro, in silico, and in vivo approaches with emerging technologies, including organ-on-chip, imaging, and omics, to address complex safety questions. Communicate integrated risk assessments : Present scientific conclusions and safety strategies to governance bodies and contribute to regulatory submissions. Provide regulatory and scientific leadership : Maintain and expand expertise in regulatory standards, preclinical safety, and modality-specific toxicology while anticipating industry trends and evolving methodologies. Support external opportunities : Provide strategic toxicology input for in-licensing evaluations, due diligence activities, and external collaborations. Build scientific influence : Advance Oncology Safety science through internal and external collaborations, publications, conference participation, and thought leadership. Develop people and partnerships : Contribute to an inclusive, collaborative environment and support the development of colleagues across teams and geographies. Essential qualifications and experience Education : PhD, DABT, or an advanced university degree in toxicology, pharmacology, oncology, or a related scientific discipline, together with a strong scientific track record. Professional experience : Typically, at least 10 years of experience in project toxicology, investigative toxicology, regulatory toxicology, or related safety-focused roles within the pharmaceutical, biotechnology, or CRO sector. Alternative experience pathway : Candidates with a minimum bachelor’s degree and substantial additional pharmaceutical industry experience may also be considered, including candidates with approximately 15 or more years of relevant experience. Oncology expertise : Deep understanding of oncology drug discovery and development, with a demonstrated ability to deliver toxicology programs supporting IND filings and broader development milestones. Modality expertise : Experience with radioconjugates or ADCs is preferred. Familiarity with small-molecule oncology therapeutics is also valuable. Translational safety skills : Experience applying in vitro, in silico, and in vivo tools to predict and characterize potential clinical safety risks. Leadership and collaboration : Ability to coordinate multiple projects across functions and geographies while working effectively in a complex, matrixed environment. Communication and influence : Strong scientific communication, interpersonal, and influencing skills, with the ability to inform decisions among scientific, clinical, and regulatory stakeholders. Commitment to

The description is cut here. Read the full offer: https://jobsbylevel.com/jobs/project-toxicologist-director-oncology-targeted-delivery-otd-safety-science-clinical-pharmacology-and-safety-sciences-cambridge-ma-or-gaithersburg-md-at-astrazeneca-147e5f

Source: https://jobsbylevel.com/jobs/project-toxicologist-director-oncology-targeted-delivery-otd-safety-science-clinical-pharmacology-and-safety-sciences-cambridge-ma-or-gaithersburg-md-at-astrazeneca-147e5f

## Cite this page

Level. https://jobsbylevel.com/jobs/project-toxicologist-director-oncology-targeted-delivery-otd-safety-science-clinical-pharmacology-and-safety-sciences-cambridge-ma-or-gaithersburg-md-at-astrazeneca-147e5f.

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