# Scientist / Senior Scientist, tLNP Formulation and Delivery at Basecamp Research

AI Level 1, AI centrality 20 out of 100. Boston.

## Details

- Company: [Basecamp Research](https://jobsbylevel.com/companies/basecamp-research)
- AI level: AI Level 1 (score 20 out of 100)
- Location: Boston
- Salary: $110k-$165k
- Posted: October 6, 2026
- Apply: https://jobsbylevel.com/go/971dff45-ebbb-411d-9325-6b6c36e38246

## Description

About us Basecamp Research is building frontier AI for therapeutic design. We believe the future of medicine lies in reprogramming the body to repair itself, and we design the models and the medicines to teach it how. Our EDEN models are trained on BaseData, the world's largest proprietary genomic dataset, with over 10B genes collected through partnerships in more than 30 countries across all seven continents. This gives our AI models access to genetic diversity that doesn't exist in public databases, and enables EDEN to design cell and gene therapies, enzymes, and peptides directly from information about a disease. Our pipeline of EDEN-designed therapeutics, beginning with in vivo cell therapy, is advancing towards clinical development. In September 2026 we closed an oversubscribed $140M Series C led by S32, with participation from NVIDIA, Anthropic's Anthology Fund, Catalio, European Tech Collective, Firebrand River Capital, King Philanthropies, NATO Innovation Fund, NVentures (NVIDIA's venture arm), Redalpine, Rockefeller Foundation, Singular, Sovereign AI and True Ventures. We have offices and labs in London and Boston, we partner with biopharma companies and academic institutions worldwide, and our work has been recognised by Fast Company's Top 10 Most Innovative Companies in Biotech, the FT-backed Sifted AI100 list of Europe's leading AI startups as well as Barclays Eagle Labs Ones to watch, AI100. At Basecamp Research, we pride ourselves on being a lean collaborative and global team with extremely specialist and unique skills. Our biologists, engineers, ML scientists and field explorers are united by a sense of adventure and the belief that AI, biology and data, will result in new medicines for patients who have few options today. The Role We are seeking a highly capable and proactive Scientist / Senior Scientist, tLNP Formulation and Delivery to join our Boston, MA team. This role reports to the Head of Gene Editing and Early Discovery and owns the end-to-end design, formulation, bioconjugation, and physicochemical characterization of novel targeted lipid nanoparticles (tLNPs). You will partner closely with our cell biology team to validate targeting and cellular uptake of AI-designed genetic medicines, while serving as the primary technical interface for in vivo studies — central to our strategy of achieving extrahepatic tissue tropism for next-generation gene and cell therapies. This is a lab-based role requiring on-site presence at our Boston, MA facility every working day. Key Responsibilities LNP technology development: Develop targeted LNP technology to enable extrahepatic tissue tropism for next-generation genetic medicines. tLNP formulation design: Design and execute tLNP formulations encapsulating nucleic acid payloads (e.g., mRNA, DNA, sgRNA, etc.), systematically altering lipid ratios, ionizable lipid structures, and helper components to drive extrahepatic tissue tropism. Lipid synthesis: be able to direct third party CRO’s to synthesize lipids of interest. Bioconjugation: Perform hands-on surface modifications and bioconjugation chemistries to attach targeting moieties (antibodies, VHHs/nanobodies, peptides) to LNP surfaces. LNP analytics: Perform routine and advanced LNP analytics, including particle size/polydispersity (e.g., dynamic light scattering), zeta potential, encapsulation efficiency (e.g., RiboGreen assays), and other relevant conjugation/purity metrics for labeled ligands. Physicochemical characterization: Perform physicochemical characterization of LNP formulations to support formulation optimization and quality assessment. In vitro assay development: Partner with our cell biology team to develop, optimize, and execute in vitro assays (using flow cytometry/FACS, plate readers, and fluorescence/luminescence imaging) to evaluate target binding, receptor-mediated cellular uptake, endosomal escape, and functional cargo translation of candidate tLNPs. In vivo study design: Partner with the

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