# Senior Principal Architect - AI ML and Cloud Security - AI Architecture at GSK

GSK is hiring a Senior Principal Architect - AI ML and Cloud Security - AI Architecture for a remote role open to applicants in India. Level rates it Works on AI ●●●○; you can [apply on GSK](https://jobsbylevel.com/go/b2f57396-a0ae-41b4-9781-37d1bc53ec64?utm_medium=ai-agent).

AI Level 3, AI centrality 65 out of 100. Remote (Bengaluru Luxor North Tower).

## Details

- Company: [GSK](https://jobsbylevel.com/companies/gsk)
- AI level: AI Level 3 (score 65 out of 100)
- Location: Remote (Bengaluru Luxor North Tower)
- Posted: November 9, 2026
- Apply: https://jobsbylevel.com/go/b2f57396-a0ae-41b4-9781-37d1bc53ec64?utm_medium=ai-agent
- Free CV review for this job: https://jobsbylevel.com/cv-review?job=senior-principal-architect-ai-ml-and-cloud-security-ai-architecture-at-gsk-1909b6

## Prepare for this job

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## Description

GSK remains committed to achieving bold commercial ambitions for the future. By 2031, we aim to deliver £40 billion in annual sales, leveraging our existing strong performance momentum to significantly increase our positive impact on the health of billions of patients globally. Our Ahead Together strategy is centred on early intervention to prevent and alter the course of disease, thereby protecting people and supporting healthcare systems. Our diverse portfolio consists of vaccines, specialty medicines, and general medicines. Through continuous innovation and a dedicated focus on scientific and technical excellence, we strive to develop and launch new, groundbreaking treatments that address critical health challenges. Domain focus: AI Architecture (agentic framework, LLM orchestration and RAG design) as a senior individual contributor at enterprise scale. Job Purpose: Senior individual contributor designing the AI solution architectures that AI Engineering builds. You own LLM orchestration patterns, agent design, RAG and retrieval boundary patterns, embedding security and API security for AI services, and you validate the agentic framework design before it is handed to Engineering. About the team. AI ML and Cloud Security is the function through which GSK is transforming security itself. The team designs and builds the agentic framework, a multi-agent platform moving security services across the Chief Security Office from rule-based to AI-driven operation. It owns AI architecture and AI engineering end to end: the agent layer, LLM orchestration, the AI and ML platform, and the data fabric pipeline that Cyber Architecture and Solutions designs, builds and tests before a managed service vendor operates it. The team also governs AI tool security posture, advises on cloud security across the Azure and GCP estate, and is the front door between GSK's business units and R&D and the technical AI function. AI security standards set here are binding on every AI initiative in GSK. Seventeen roles across the UK, India and the US. What makes this role different. A pure architecture role with no line management and real design authority: your specifications are what Engineering builds from, and if they are ambiguous the build is wrong. You will be asked to whiteboard an agentic or RAG architecture you designed, including how you handled prompt injection and data classification across a retrieval boundary. Familiarity with reference architectures, without designs that were actually built and operated, will not get through that conversation. Key responsibilities: This role will provide you the opportunity to lead key activities to progress your career. These responsibilities include some of the following: Design AI solution architectures: LLM orchestration patterns, agent design, RAG and retrieval boundary patterns, embedding security, and API security for AI services. Validate the agentic framework design before handoff to Engineering and confirm it is buildable, testable and operable. Author the pattern library entries for LLM orchestration, retrieval boundaries and tool-calling scopes that engineering teams build from. Lead architecture reviews for new AI tool proposals and assess them against Cyber Architecture and Solutions standards. Contribute to the data fabric architecture and the controls applied at each classification boundary. Produce specifications detailed enough that Engineering builds without reinterpretation. Apply the binding AI security standards and threat models to every design, escalating where a design cannot meet them rather than diluting them. Support use-case feasibility assessment for business and R&D proposals. Sit in the agentic framework build stand-ups and answer design questions the same day, so the build never stalls on an absent architect. Review the agent and RAG designs produced by the other architects and sign them off or send them back; you are the technical second opinion in a team with no line

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Source: https://jobsbylevel.com/jobs/senior-principal-architect-ai-ml-and-cloud-security-ai-architecture-at-gsk-1909b6

## Cite this page

Level. https://jobsbylevel.com/jobs/senior-principal-architect-ai-ml-and-cloud-security-ai-architecture-at-gsk-1909b6.

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