# Senior Scientist, Formulation Delivery Systems at CSL

CSL is hiring a Senior Scientist, Formulation Delivery Systems. It pays $126k-$157k a year and Level rates it Little AI ●○○○; you can [apply on CSL](https://jobsbylevel.com/go/cd472712-c0e1-41ac-8811-9fde67807d35?utm_medium=ai-agent).

AI Level 1, AI centrality 30 out of 100. Americas, US-MA, Waltham, CSL Behring.

## Details

- Company: [CSL](https://jobsbylevel.com/companies/csl)
- AI level: AI Level 1 (score 30 out of 100)
- Location: Americas, US-MA, Waltham, CSL Behring
- Salary: $126k-$157k
- Posted: November 5, 2026
- Apply: https://jobsbylevel.com/go/cd472712-c0e1-41ac-8811-9fde67807d35?utm_medium=ai-agent
- Free CV review for this job: https://jobsbylevel.com/cv-review?job=senior-scientist-formulation-delivery-systems-at-csl-2935ed

## Description

Senior Scientist, Delivery Technologies CSL's organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we're building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide. Could you be our next Senior Scientist, Delivery Technologies? Work Environment: This position is based in Waltham, MA and is an onsite role 5 days each week. CSL is not providing relocation assistance or visa sponsorship. You will report to the Principal Scientist, Delivery Technologies The successful candidate will provide scientific expertise in the design, formulation, characterization, and optimization of delivery technologies to support drug discovery efforts across multiple functions and external collaborations. This role requires strong expertise in lipid nanoparticle (LNP) formulation, extra-hepatic targeted delivery approaches, siRNA-conjugates to enable tissue- and cell-specific delivery, and extensive knowledge in translational drug delivery sciences. Key Responsibilities Contribute and support CSL’s novel modalities portfolio and pipeline Participate in external due diligence, assessing delivery system suitability for various modalities, technical feasibility, and risk Lead the design, formulation, and characterization of LNPs containing siRNA, mRNA, gene-editing cargoes, and other nucleic acid modalities Design and execute Design of Experiment (DOE) principles in formulation screening Work on medium to high throughput formulation preparation Optimize formulation parameters, lipid composition, manufacturing processes, and excipient systems to enhance stability and biological performance Develop and characterize targeted delivery strategies (t-LNP) utilizing receptor-mediated uptake mechanisms, targeting ligands, and tissue-specific delivery approaches Lead efforts related to the design and evaluation of ligand-siRNA conjugates for extrahepatic delivery Evaluate delivery performance through in vitro and in vivo studies, including cellular uptake, endosomal escape, biodistribution, and target engagement Serve as a subject matter expert in delivery approaches and LNP process development, and provide technical delivery-related support across research, development, and manufacturing activities Apply mechanistic insights into critical process parameters and product attributes through hypothesis-driven experimentation, robust data analysis, and problem-solving Provide scientific guidance and mentorship to team members and collaborate closely with Analytical Biochemistry and Molecular Biology teams Minimum Qualifications: PhD with 5+ years or MS with 7+ years of relevant experience in Pharmaceutical Sciences, Nanomedicine, Biomedical Engineering, Chemistry, Chemical Engineering, Drug Delivery, in the pharmaceutical industry Demonstrated ability to independently lead scientific projects and experience working in cross-functional research environments Strong track record in LNP formulation and optimization Expertise in nanoparticle characterization techniques including particle size, encapsulation efficiency, and stability assessment Expertise in in vitro and in vivo evaluation of RNA-based delivery systems Understanding of cellular uptake mechanisms, intracellular trafficking, and endosomal escape Demonstrated experience with targeted LNPs and extrahepatic delivery platforms Experimental design, statistical analysis, and data interpretation Preferred: Knowledge of medicinal chemistry principles related to ionizable lipid design, structure-activity relationships (SAR), ligand optimization and linker chemistry The minimum and maximum base salary range that CSL expects to pay for this position at the Waltham, MA USA work location at the time of this posting is $126,000/yr - $157,000/yr. Individual base salary for a successful candidate is

The description is cut here. Read the full offer: https://jobsbylevel.com/jobs/senior-scientist-formulation-delivery-systems-at-csl-2935ed

Source: https://jobsbylevel.com/jobs/senior-scientist-formulation-delivery-systems-at-csl-2935ed

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