# Senior Scientist - Protein Expression and Purification at LabGenius

LabGenius is hiring a Senior Scientist - Protein Expression and Purification in London, United Kingdom. Level rates it Little AI ●○○○; you can [apply on LabGenius](https://jobsbylevel.com/go/d2dc2122-4918-4567-8d11-06877e95f8a0?utm_medium=ai-agent).

AI Level 1, AI centrality 30 out of 100. London, United Kingdom.

## Details

- Company: [LabGenius](https://jobsbylevel.com/companies/labgenius)
- AI level: AI Level 1 (score 30 out of 100)
- Location: London, United Kingdom
- Posted: November 11, 2026
- Apply: https://jobsbylevel.com/go/d2dc2122-4918-4567-8d11-06877e95f8a0?utm_medium=ai-agent
- Free CV review for this job: https://jobsbylevel.com/cv-review?job=senior-scientist-protein-expression-and-purification-at-labgenius-c55b9f

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## Description

At LabGenius Therapeutics ("LabGenius"), our mission is to discover the next generation of therapeutic antibodies by combining human and machine intelligence. To do this, we’ve pioneered the development of EVA™, state-of-the-art automated platform, enabling the closed-loop discovery of high-performing, non-intuitive antibody designs using proprietary, ML-grade datasets. For our wholly-owned therapeutic pipeline, we’re using our closed-loop discovery engine to establish a pipeline of highly selective T-cell engagers and ADCs for the treatment of solid tumours. LabGenius has raised >£55M and is backed by top-tier investors, including M Ventures, Octopus Ventures, LG Corp, Atomico, Kindred Capital, Lux Capital and Obvious Ventures amongst others. The company is headquartered in London (UK) where we’ve established a cutting-edge antibody engineering facility. The company is staffed by a multidisciplinary team of more than 50 scientists and engineers. You’ll be a pivotal member of the Antibody Engineering and Developability team, serving as our technical lead for protein expression and purification. This is a high-impact opportunity for a protein sciences expert to not only execute complex workflows, but to build, scale, and optimise our protein expression platform, including spearheading the establishment of our stable cell line capabilities. Your primary mission is to ensure that our ML models and downstream screening platforms are fed with high-quality, ultra-pure protein and antibody reagents. You won't just be running samples; you will be spearheading our initiative to establish stable cell pools in CHO while managing the entire gene-to-protein workflow from cloning and large-scale DNA production through to final purification. You’ll be a member of our core wet-lab team, where you’ll ensure that complex therapeutic candidates can be produced reliably and at scale. You won't just be expressing proteins; you’ll be troubleshooting complex constructs, identifying expression bottlenecks early in the pipeline, and ensuring our therapeutics possess the developability profiles required to become successful products. Whatever your previous experience includes, you’ll inject passion and energy into everything you do. You’ll enjoy multi-disciplinary work, and you’ll have a hunger for knowledge, learning, and growth; all the qualities LabGenius Therapeutics celebrates! Your role at LabGenius Therapeutics will be varied, with clear communication being critical to your day-to-day interactions with the team. Being able to integrate your workflow with other teams, along with the ability to share findings in an articulate manner, will help you to achieve success within this position. This position is a full time laboratory-based role. What you’ll do in this role Lead the transient expression of complex recombinant proteins, bispecifics, and fusion proteins in mammalian hosts at multi-milligram to gram scales. Oversee molecular cloning, construct design, and large-scale plasmid DNA production workflows to support both transient transfections and stable cell line generation. Establish internal stable cell line capabilities, specifically establishing and validating stable cell pools in CHO hosts for the production of lead antibody candidates. Design and execute multi-step purification strategies utilising automated FPLC systems (e.g., AKTA Pure) focusing on Affinity, IEX, HIC, and SEC. Implement and manage robust inventory management and barcoding systems to ensure end-to-end traceability of plasmids, cell lines, purified proteins, and critical reagents. Work closely with our Data Science team to translate raw expression yields, purity metrics, and biophysical data into clean datasets for ML/AI predictive models, ensuring our in silico scoring is grounded in precise physical measurements. Conduct research in a self-directed manner, troubleshooting low-yielding or challenging protein constructs by optimising signal peptides, expression vectors,

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