Postdoctoral Research Fellow – Endogenous Biomarkers and Translational ADME

Goal

We are seeking a highly motivated Postdoctoral Fellow to advance the discovery, mechanistic qualification, and clinical translation of endogenous biomarkers of cytochrome P450 (CYP) enzyme activities. Reliable assessment of CYP inhibition and induction is important for predicting clinical drug-drug interactions, but available endogenous biomarkers remain limited by biological variability, insufficient sensitivity, and incomplete mechanistic understanding. The successful candidate will lead experimental and analytical research toward establishing a mechanistically qualified biomarker panel by integrating clinical biomarker analysis, multiplex LC-MS/MS bioanalysis, mechanistic ADME studies, pharmacokinetic data analysis, and physiologically based pharmacokinetic modeling.

What You Will Achieve

In this role, you will:

• Evaluate candidate biomarkers across diverse clinical datasets and investigate biological and mechanistic factors that influence their performance.
• Determine how metabolic enzymes, membrane transporters, renal and biliary clearance, and enterohepatic processes influence biomarker disposition.
• Identify and mechanistically explain variability or discordance among candidate biomarkers.
• Develop a quantitative relationship between endogenous biomarker responses and changes in the pharmacokinetics of sensitive CYP substrates.
• Advance the scientific foundation for incorporating endogenous biomarkers into clinical DDI assessment and drug-development decision-making.
• Develop expertise across bioanalysis, mechanistic ADME, clinical pharmacology, quantitative modeling, and scientific communication.

Here Is What You Need (Minimum Requirements):

• PhD in pharmaceutical sciences, pharmacology, pharmacokinetics, drug metabolism, analytical chemistry, biochemistry, biomedical sciences, chemical biology, quantitative pharmacology, or a closely related discipline.
• Strong scientific training in at least one area directly relevant to the project, such as bioanalysis, metabolomics, drug metabolism, mechanistic ADME, enzymology, membrane transporter science, pharmacokinetics, or quantitative pharmacology, with demonstrated ability or interest in working across multiple scientific disciplines.
• Relevant hands-on research experience in bioanalysis, in vitro drug metabolism, membrane transporter research, or another experimental area directly related to mechanistic ADME.
• Demonstrated experience designing, conducting, analyzing, and interpreting hypothesis-driven research.
• Ability to critically analyze complex experimental or quantitative datasets and draw scientifically supported conclusions.
• Evidence of scientific productivity through peer-reviewed publications, submitted manuscripts, conference presentations, or comparable research contributions.
• Strong written and verbal communication skills, including the ability to present research findings clearly and contribute to scientific manuscripts.
• Ability to work effectively and collaboratively in a multidisciplinary research environment.
• Strong organizational skills, attention to experimental detail, and the ability to manage multiple research activities.

Bonus Points If You Have (Preferred Requirements):

• Strong hands-on experience with quantitative LC-MS/MS, including assay development, optimization, and analysis of small molecules, metabolites, or endogenous biomarkers in biological matrices.
• Hands-on experience with in vitro ADME assays, with preference for experience using recombinant CYP enzymes, human liver microsomes, or hepatocytes; relevant transporter-assay experience is also highly valued.
• Strong knowledge of pharmacokinetic and drug-drug interaction principles, including clearance, exposure, concentration-time relationships, and interpretation of inhibition or induction effects.
• Familiarity with PBPK modeling, population pharmacokinetics, pharmacometrics, or other mechanistic modeling approaches.
• Experience using scientific data-analysis software, such as R, Python, MATLAB, or comparable tools.
• Demonstrated ability to integrate bioanalytical, mechanistic, and quantitative data and communicate conclusions clearly.
• Strong interest in multidisciplinary translational research and in developing expertise beyond the candidate’s primary area of training.
  

  
Relocation support available

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.