Iambic TherapeuticsPrincipal Scientist, Medicinal Chemistry
Iambic Therapeutics is hiring a Principal Scientist, Medicinal Chemistry in San Diego, United States. It pays $152k-$190k a year and Level rates it ; you can apply on Iambic Therapeutics.
Level's read on this job
- Level rates this role Uses AI ●●○○: an ordinary role that requires AI tools.
- The posting mentions medicinal chemistry, synthetic organic chemistry and drug discovery among its tools and skills.
- Level classes it as a senior role.
- Iambic Therapeutics has 29 other open roles on Level.
AI in this role
Design and optimize lead molecules in drug discovery while interfacing with automated experimentation and AI-driven molecular generation teams.
JOB SUMMARY
We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
This position is on-site at our San Diego Headquarters.
KEY RESPONSIBILITIES
Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.
Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques.
Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
Communicate project updates clearly and effectively to the broader team and key stakeholders
Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork
QUALIFICATIONS
BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry
Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 15+ years’ experience, M.S. with 12+ years’ experience or Ph.D. with 8+ years’ experience.
Proven track record of success in advancing programs from leads to advanced candidates.
Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
Ability to integrate multiple R&D disciplines into a successful strategic project plan
Experience working with computational chemists as part of project team in design of drug targets is required
Strong interpersonal, communication, time management, and leadership skills
Creative problem solving and management of relationships with several stakeholders within and beyond the company
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
How we rate this
Principal Scientist, Medicinal Chemistry at Iambic Therapeutics rates 50 out of 100 for how much of the daily work is AI. That makes it Uses AI (AI Level 2 of 4). The level is about AI in the job, not seniority.
Uses AI. An ordinary role that requires AI tools.
- ●●●● Builds AI80 to 100
- ●●●○ Works on AI60 to 79
- ●●○○ Uses AI40 to 59
- ●○○○ Little AI0 to 39
Levels come from how often the tools, models and workflows of the role are named in the posting itself. Read the description and count the AI tools, models and workflows it names.
Prepare for this job
Built from this posting and from similar jobs on Level.
Skills and AI tools this role asks for
Questions you could be asked
- Tell me about a project where medicinal chemistry was part of your work. What did you do?
- Tell me about a project where synthetic organic chemistry was part of your work. What did you do?
- Tell me about a project where drug discovery was part of your work. What did you do?
- Tell me about a project where sar analysis was part of your work. What did you do?
- Tell me about a project where computational chemistry was part of your work. What did you do?
Adapt your resume
- List these exact terms on your resume: Medicinal Chemistry, Synthetic Organic Chemistry, Drug Discovery, Sar Analysis, and Computational Chemistry. An applicant tracking system matches the wording, not the idea.
- Attach one line of real, concrete experience to at least one of them. A tool named with nothing behind it rarely survives a human read.
- Put the AI tool in a bullet point about what you did, not just in a skills list. This role treats it as a required part of the job.
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