Iambic TherapeuticsSr Associate Scientist I or II, Medicinal Chemistry
Iambic Therapeutics is hiring a Sr Associate Scientist I or II, Medicinal Chemistry in San Diego, United States. It pays $84k-$120k a year and Level rates it ; you can apply on Level.
Level's read on this job
- Level rates this role Works on AI ●●●○: the daily work is on AI products, without building the model.
- The posting mentions Lcms, Hplc and Nmr among its tools and skills.
- Level classes it as a senior role.
- Iambic Therapeutics has 31 other open roles on Level.
- This posting went up within the past two weeks.
AI in this role
Design and synthesize chemical compounds in collaboration with computational chemists and machine learning researchers to drive AI-driven drug discovery programs.
JOB SUMMARY
We are seeking a highly skilled and motivated Senior Associate Scientist to join the Chemistry team at Iambic Therapeutics headquarters in San Diego. This position offers the opportunity to work within a dynamic, cross-functional environment, collaborating closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning researchers, and software engineers throughout all stages of discovery, from hit identification and lead optimization through candidate selection. This is a laboratory-based Associate Scientist position that requires strong technical expertise in organic synthesis, catalysis, and medicinal chemistry, as well as hands-on experience in the drug discovery process and a demonstrated “drug hunter” mindset.
KEY RESPONSIBILITIES
Design, synthesize, purify, and characterize chemical compounds (10 mg–5 g scale) using modern analytical techniques such as LCMS, HPLC, and NMR, employing both individual and automated parallel synthesis approaches.
Identify and optimize reaction conditions using screening kits and other streamlined methodologies.
Collaborate with the high-throughput experimentation team to ensure the successful execution of parallel chemistry experiments.
Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning.
Partner with computational chemists to leverage machine learning insights for efficient execution of the design–make–test cycle and platform development.
Present results to project teams and senior leadership, clearly communicating data, implications, and recommendations.
QUALIFICATIONS
BS in Chemistry with 5+ years experience (pharma/biotech) or MS in Chemistry with 3+ years experience (pharma/biotech).
Proven skills in multi-step organic synthesis, reaction optimization, SAR analysis, and scientific presentation.
Ability to thrive in a fast-paced, highly collaborative research environment.
Availability to work onsite in San Diego.
PREFERRED QUALIFICATIONS
Prior exposure to high-throughput experimentation.
Familiarity with ADME-PK principles.
5+ years of experience contributing to drug discovery projects.
Experience with molecular modeling and structure-based drug design
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
How we rate this
Sr Associate Scientist I or II, Medicinal Chemistry at Iambic Therapeutics rates 60 out of 100 for how much of the daily work is AI. That makes it Works on AI (AI Level 3 of 4). The level is about AI in the job, not seniority.
Works on AI. The daily work is on AI products, without building the model.
- ●●●● Builds AI80 to 100
- ●●●○ Works on AI60 to 79
- ●●○○ Uses AI40 to 59
- ●○○○ Little AI0 to 39
Levels come from how often the tools, models and workflows of the role are named in the posting itself. Open the description and count.
Prepare for this job
Built from this posting and from similar jobs on Level.
Skills and AI tools this role asks for
Questions you could be asked
- Tell me about a project where medicinal chemistry was part of your work. What did you do?
- Tell me about a project where organic synthesis was part of your work. What did you do?
- Tell me about a project where drug discovery was part of your work. What did you do?
- Tell me about a project where cheminformatics was part of your work. What did you do?
- Walk me through how you've used Lcms in your day-to-day work.
Adapt your resume
- List these exact terms on your resume: Medicinal Chemistry, Organic Synthesis, Drug Discovery, Cheminformatics, and Lcms. An applicant tracking system matches the wording, not the idea.
- Attach one line of real, concrete experience to at least one of them. A tool named with nothing behind it rarely survives a human read.
- Show where AI is part of your daily process, not a one-off project. This role expects it to be a running habit.
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