Principal Scientist II - Pharmacology

Novartis is hiring a Principal Scientist II - Pharmacology. It pays $126k-$234k a year and Level rates it ; you can apply on Novartis.

Level's read on this job

Little AI ●○○○ is how Level rates this role: aI is not part of the work.
Tools and skills the posting cites include Pcr, Elisa and Flow Cytometry.
Level classifies it as a senior role.
Level lists 856 other open roles at Novartis.

AI in this role

Principal Scientist leading in vivo oncology pharmacology studies and evaluating novel cancer therapies in Cambridge, MA.

PcrElisaFlow Cytometry

pharmacologyin-vivooncologydrug-discovery

Job Description Summary

#LI-Onsite
Location: Cambridge, MA
This position is located in Cambridge, MA and does not have the ability to be located remotely. Please only apply if this area is accessible to you.

Over 40 therapies in the clinic! NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline. This is a labhead-based position, where the ideal candidate is expected to lead efforts in the design and execution of in vivo anti-tumor efficacy and PK/PD studies aimed at evaluating drug candidates in CDX, PDX, and syngeneic models. Applicants are expected to develop novel in vivo assays to interrogate key scientific questions and deliver high-value translationally relevant data that can inform clinical development. Qualified candidates will have extensive experience in a variety of molecular biology skills. A strong background and expertise in antibody drug conjugates is preferred. We are looking for highly motivated, inquisitive, and creative individuals, who thrive in a highly matrixed work environment, and can effectively communicate within multidisciplinary project teams.

Job Description

Responsibilities:

Design pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalities
Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions
Manage associate-level scientists
Collaborate with cross-functional project teams
Critically analyze and present results within a multidisciplinary team environment
Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook

Qualifications:

PhD with 5-8 years of research experience as a postdoc or in the pharmaceutical/biotech industry
Deep knowledge of antibody drug conjugates
Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models
Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry
Strong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Prism and Excel

Novartis Compensation and Benefit Summary:

The salary for this position is expected to range between $126,000 and $234,000 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and

experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published

salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the

role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and

disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

$126,000.00 - $234,000.00

Skills Desired

Analytical Skill (Inactive), Analytical Skill (Inactive), Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Communication Skills (Inactive), Curious Mindset, Data (Inactive), Data Analysis, Design of Experiments (DOE), Detail-Oriented, Drug Development, Drug Discovery Process, Ethics, Gene Therapy, Immunology, Inventory Management, Laboratory (Inactive), Leading Project Teams, Lifesciences (Inactive), Machine Learning (ML), Management (Inactive), Medical Research {+ 10 more}

How we rate this

Principal Scientist II - Pharmacology at Novartis rates 0 out of 100 for how much of the daily work is AI. That makes it Little AI (AI Level 1 of 4). The level is about AI in the job, not seniority.

Classification

Little AI. AI is not part of the work.

●●●● Builds AI80 to 100
●●●○ Works on AI60 to 79
●●○○ Uses AI40 to 59
●○○○ Little AI0 to 39

Levels come from how often the tools, models and workflows of the role are named in the posting itself. Read the description and count the AI tools, models and workflows it names.

Key facts

Principal Scientist II - Pharmacology is an open job at Novartis.
Level rates this role AI Level 1 of 4: Little AI.
The listed salary is $126k-$234k a year.
The role is based in Cambridge (USA).
The job was posted on July 9, 2026.
Seniority: senior.
Applications are handled by Novartis. Apply on Novartis

Prepare for this job

Built from this posting and from similar jobs on Level.

Skills and AI tools this role asks for

PharmacologyIn VivoOncologyDrug DiscoveryPcrElisaFlow Cytometry

Questions you could be asked

Tell me about a project where pharmacology was part of your work. What did you do?
Tell me about a project where in vivo was part of your work. What did you do?
Tell me about a project where oncology was part of your work. What did you do?
Tell me about a project where drug discovery was part of your work. What did you do?
Walk me through how you've used Pcr in your day-to-day work.

Adapt your resume

List these exact terms on your resume: Pharmacology, In Vivo, Oncology, Drug Discovery, and Pcr. An applicant tracking system matches the wording, not the idea.
Attach one line of real, concrete experience to at least one of them. A tool named with nothing behind it rarely survives a human read.

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