Associate Scientist in Protein Mass Spectrometry

ROLE SUMMARY

Pfizer currently has an open position for an Associate Scientist in Protein Mass Spectrometry (MS) within the Structural Analytical and Molecular Sciences (SAMS) department in Groton, CT. We are seeking a highly motivated individual with strong expertise in biochemistry and experimental protein characterization. Experience in native MS, nanoelectrospray applications or MS characterization of large molecules is a strong plus. The successful candidate will demonstrate scientific proficiency from the bench, be a fast learner of new skills, and work effectively in a matrix team environment.

We are an integrated and highly collaborative team of colleagues with technical expertise across molecular biology, protein biochemistry, biophysics, and structural biology. We have a strong track record of enabling hit-to-lead progression for small molecule modulators of diverse protein targets using integrated biophysical and structural approaches. We actively collaborate with Pfizer drug discovery teams across multiple therapeutic areas by providing comprehensive molecular and structural insights into therapeutic targets, lead molecules, and protein-ligand interactions.

ROLE RESPONSIBILITIES

• Learn and deploy native MS and other structural MS methods for deep characterization of protein-ligand interactions
• Handle and manipulate protein samples to enable and execute quantitative and qualitative binding studies.
• Support and maintain open-access MS systems for a suite of users and assist with data collection and processing where needed.
• Be part of multi-disciplinary teams to support discovery projects across diverse disease areas.
• Effective oral and written communication of experimental work and analysis.
• Perform timely notebook entries and review for completed experiments.

QUALIFICATIONS

• BS in chemistry, biochemistry, biophysics, molecular biology or related field with ~1-3 years of relevant laboratory experience.
• Skill and familiarity with handling and manipulating recombinant protein samples
• Ability to multi-task to balance parallel activities.
• Ability to troubleshoot scientific and technical challenges and contribute to their resolution.
• Previous experience with mass spec instrumentation and data analysis is a strong plus.
• Experience using common AI tools, including generative technologies such as ChatGPT or Microsoft Copilot, to support problem solving and enhance productivity.
• Demonstrated curiosity for exploring how these tools can improve outcomes and understanding of responsible AI practices, including risk management and ethical use.

PHYSICAL/MENTAL REQUIREMENTS

Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Minimal, if any travel related to this position.
• Candidate must comply with laboratory safety practices

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

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To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.