NovartisPrincipal Scientist/Senior Scientist, Cryo-EM Structural Biology
Novartis is hiring a Principal Scientist/Senior Scientist, Cryo-EM Structural Biology. It pays CHF 94k-CHF 174k a year and Level rates it ; you can apply on Novartis.
Level's read on this job
- Little AI ●○○○ is how Level rates this role: aI is not part of the work.
- Tools and skills the posting cites include cryo em, structural biology and protein sciences.
- Level classifies it as a senior role.
- Level lists 870 other open roles at Novartis.
- The role was posted within the past week.
AI in this role
Apply Cryo-EM structural biology techniques to support early drug discovery projects in Basel.
Salary Range:
CHF93,800.00 - CHF174,200.00
Job Description Summary
Role Type: Onsite Working, #LI-OnsiteLocation: Basel, Switzerland
Relocation Support: This role is based in Basel, Switzerland. Novartis is unable to offer relocation support: please only apply if accessible.
What if your expertise in structural biology could reveal the molecular insights that unlock the next generation of medicines? As Principal Scientist/Senior Scientist, Cryogenic Electron Microscopy (Cryo-EM) Structural Biology, you will join the Protein Sciences group within Discovery Sciences, applying cutting-edge Cryo-EM to challenging targets across early drug discovery. Working with scientists across Biomedical Research, you will prepare biological samples, generate and interpret high-quality structural data, and translate molecular insights into actionable science that supports the discovery of novel therapeutic candidates.
Job Description
Key Responsibilities:
- Contribute experimentally and scientifically to early drug-discovery projects within multidisciplinary teams.
- Prepare biological samples for Cryo-EM, including data collection, processing, structural determination, and model building.
- Apply current Cryo-EM technologies and methodologies to generate high-quality structural insights for drug discovery.
- Collaborate closely with laboratory associates, providing mentoring and technical training within a matrix environment.
- Maintain accurate experimental records, scientific documentation, and instrument logs to support data quality and reproducibility.
- Communicate structural biology findings through internal and external presentations and scientific publications.
Essential Requirements:
- PhD in a relevant scientific discipline with at least five years of research experience, or an equivalent combination of training and experience.
- Deep expertise in Cryo-EM, including sample preparation, single-particle analysis, structure determination, model building, and structural interpretation.
- Hands-on experience operating high-end cryo-transmission electron microscopes.
- Demonstrated experience in the expression and purification of a range of protein targets.
- Excellent written and spoken English, with strong scientific communication and presentation skills.
- Strong analytical skills, attention to detail, and a collaborative approach to working within multidisciplinary scientific teams.
Desirable Requirements:
- Experience troubleshooting and optimizing experimental and data-processing workflows for single-particle analysis and cryo-electron tomography.
- Familiarity with artificial intelligence-based and computational tools for protein construct design and optimization.
- Experience characterizing protein-ligand interactions.
- Hands-on experience with single-particle analysis, cryo-electron tomography, and dual-beam scanning electron microscopy.
Why Novartis:
At Novartis, you will join a collaborative Protein Sciences team applying complementary technologies, including biophysics, Nuclear Magnetic Resonance spectroscopy, X-ray crystallography, and Cryo-Electron Microscopy, to advance target-based drug discovery and novel therapeutic candidates.
Benefits & Rewards:
At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
Expected Annual Base Salary Range for role: 93,800.00 - 174,200.00 CHF
The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.
In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.
The rewards of being part of our team go far beyond base pay and incentives.
We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave.
Read our brochure to learn more about our global total rewards offering:
https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf
Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the application process.
Commitment to Diversity and Inclusion / EEO paragraph:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.
Skills Desired
Analytical Chemistry, Analytical Laboratory Equipment, Analytical Thinking, Chemical Analysis, Chemistry, Data Capturing, Data Science, Digital Workflows, Employee Development, Employee Performance Management, High-Performance Liquid Chromatography (HPLC), Laboratory Automation, Life Sciences R&D, Machine Learning (ML), Physicochemical Characterization, Python (Programming Language), Scientific Publications, Spectrometry, Spectroscopy, Therapeutic ModalitiesHow we rate this
Principal Scientist/Senior Scientist, Cryo-EM Structural Biology at Novartis rates 10 out of 100 for how much of the daily work is AI. That makes it Little AI (AI Level 1 of 4). The level is about AI in the job, not seniority.
Little AI. AI is not part of the work.
- ●●●● Builds AI80 to 100
- ●●●○ Works on AI60 to 79
- ●●○○ Uses AI40 to 59
- ●○○○ Little AI0 to 39
Levels come from how often the tools, models and workflows of the role are named in the posting itself. Read the description and count the AI tools, models and workflows it names.
Prepare for this job
Built from this posting and from similar jobs on Level.
Skills and AI tools this role asks for
Questions you could be asked
- Tell me about a project where cryo em was part of your work. What did you do?
- Tell me about a project where structural biology was part of your work. What did you do?
- Tell me about a project where protein sciences was part of your work. What did you do?
- Tell me about a project where drug discovery was part of your work. What did you do?
- Tell me about a project where biochemistry was part of your work. What did you do?
Adapt your resume
- List these exact terms on your resume: Cryo Em, Structural Biology, Protein Sciences, Drug Discovery, and Biochemistry. An applicant tracking system matches the wording, not the idea.
- Attach one line of real, concrete experience to at least one of them. A tool named with nothing behind it rarely survives a human read.
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