Senior Associate Scientist I/II, Purification Sciences

Iambic Therapeutics is hiring a Senior Associate Scientist I/II, Purification Sciences in San Diego, United States. It pays $88k-$128k a year and Level rates it ; you can apply on Iambic Therapeutics.

Level's read on this job

Level rates this role Little AI ●○○○: aI is not part of the work.
Tools and skills the posting cites include Preparative Lc, Sfc and Lc Ms.
Level classifies it as a mid-level role.
Level lists 29 other open roles at Iambic Therapeutics.

AI in this role

Perform chromatography-based purification and analytical QC to support small-molecule drug discovery chemistry efforts.

Preparative LcSfcLc Ms

chromatographypurificationanalytical-chemistrysmall-molecule-drug-discovery

JOB SUMMARY

We are seeking a motivated and hands-on Senior Associate Scientist I/II, Purification Sciences to support small-molecule drug discovery. This individual will perform chromatography-based purification, with a focus on preparative LC and preparative SFC, supporting medicinal chemistry and high-throughput chemistry efforts.

The ideal candidate will have practical laboratory experience with chromatographic purification and a strong interest in developing expertise in separation science, instrumentation, and high-throughput purification workflows. Experience with instrument maintenance and troubleshooting is highly desirable. This position will be based in our San Diego Headquarters.

KEY RESPONSIBILITIES

Perform routine and moderately complex small-molecule purification using preparative LC and SFC, supporting medicinal chemistry and high-throughput chemistry workflows.
Develop and optimize purification methods, including column/mobile-phase selection, gradients, sample loading, and fraction collection.
Operate prep LC, prep SFC, analytical LC, and LC/MS systems and perform analytical QC of purified compounds.
Perform routine instrument maintenance and troubleshoot common chromatography, fluidics, hardware, and software issues.
Monitor instrument performance and proactively identify issues to maintain reliable laboratory operations and minimize downtime.
Support high-throughput and automated purification workflows, including sample submission, purification, fraction handling, compound recovery, and data reporting.
Work closely with medicinal chemists and other scientists to prioritize samples and deliver purified compounds with appropriate purity, recovery, and turnaround time.
Support evaluation and implementation of new purification methods, columns, instrumentation, and workflow improvements.
Maintain accurate experimental and instrument documentation and contribute to laboratory best practices.

QUALIFICATIONS

B.S. or M.S. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 3+ years of experience
Relevant hands-on laboratory experience in chromatography and small-molecule purification; level will be determined based on experience and demonstrated technical capabilities.
Working knowledge of chromatographic separation principles and method optimization.
Strong attention to detail, problem-solving skills, and ability to work effectively in a fast-paced, collaborative research environment.

PREFERRED QUALIFICATIONS

Experience with preparative LC and/or preparative SFC is strongly preferred; SFC experience is highly desirable.
Experience operating and troubleshooting chromatography instrumentation is strongly preferred.
Experience with LC/MS-based characterization and purity assessment is desirable.
Experience with automated or high-throughput laboratory workflows is desirable.
Experience with Agilent, Shimadzu, SCIEX, or comparable platforms is a plus.

ABOUT IAMBIC THERAPEUTICS

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

MISSION & CORE VALUES

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

PAY AND BENEFITS

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.

How we rate this

Senior Associate Scientist I/II, Purification Sciences at Iambic Therapeutics rates 10 out of 100 for how much of the daily work is AI. That makes it Little AI (AI Level 1 of 4). The level is about AI in the job, not seniority.

Classification

Little AI. AI is not part of the work.

●●●● Builds AI80 to 100
●●●○ Works on AI60 to 79
●●○○ Uses AI40 to 59
●○○○ Little AI0 to 39

Levels come from how often the tools, models and workflows of the role are named in the posting itself. Read the description and count the AI tools, models and workflows it names.

Key facts

Senior Associate Scientist I/II, Purification Sciences is an open job at Iambic Therapeutics.
Level rates this role AI Level 1 of 4: Little AI.
The listed salary is $88k-$128k a year.
The role is based in San Diego HQ.
The job was posted on September 9, 2026.
Seniority: mid.
Applications are handled by Iambic Therapeutics. Apply on Iambic Therapeutics

Prepare for this job

Built from this posting and from similar jobs on Level.

Skills and AI tools this role asks for

ChromatographyPurificationAnalytical ChemistrySmall Molecule Drug DiscoveryPreparative LcSfcLc Ms

Questions you could be asked

Tell me about a project where chromatography was part of your work. What did you do?
Tell me about a project where purification was part of your work. What did you do?
Tell me about a project where analytical chemistry was part of your work. What did you do?
Tell me about a project where small molecule drug discovery was part of your work. What did you do?
Walk me through how you've used Preparative Lc in your day-to-day work.

Adapt your resume

List these exact terms on your resume: Chromatography, Purification, Analytical Chemistry, Small Molecule Drug Discovery, and Preparative Lc. An applicant tracking system matches the wording, not the idea.
Attach one line of real, concrete experience to at least one of them. A tool named with nothing behind it rarely survives a human read.

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